Michigan moves to No. 1 in AP poll


Michigan is No. 1 in The Associated Press' college basketball poll for the first time since its Fab Five days 20 years ago.


For the second straight week the No. 1 team lost. This time it was Duke, which was routed 90-63 by Miami in the third-worst defeat by a top-ranked team.


Michigan received 51 first-place votes from the 65-member national media panel Monday. Kansas moved up one spot to No. 2 and had 13 first-place votes. They are the only one-loss teams in the poll. Indiana, Florida, which drew the other first-place vote, and Duke complete the top five.


The Wolverines advanced from No. 2 to become No. 1 for the fourth time. They were at the top for 10 weeks in 1964-65, eight weeks in 1976-77 and three weeks at the start of 1992-93, the Fab Five's second season together.


That season, Chris Webber, Juwan Howard, Jalen Rose, Jimmy King and Ray Jackson made it to the national championship game for the second straight year.


Michigan is the second Big Ten team to be No. 1 this season. Indiana was the preseason No. 1 and stayed there for the first five weeks of the regular season. Duke moved in for four weeks before Louisville and the Blue Devils both held it for one week.


Rounding out the top 10 are No. 6 Syracuse, followed by Gonzaga, Arizona, Butler and Oregon. Miami rode its win over Duke to a 13-place jump in the poll, from 25th to 14th.


Fourteen ranked teams, including half the top 10, lost at least one game last week. Four teams, including Louisville, which dropped from fifth to 12th, lost twice last week.


San Diego State and Marquette returned to the rankings this week, replacing Virginia Commonwealth, which was 19th, and Notre Dame, which was 24th.


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Well: Keeping Blood Pressure in Check

Since the start of the 21st century, Americans have made great progress in controlling high blood pressure, though it remains a leading cause of heart attacks, strokes, congestive heart failure and kidney disease.

Now 48 percent of the more than 76 million adults with hypertension have it under control, up from 29 percent in 2000.

But that means more than half, including many receiving treatment, have blood pressure that remains too high to be healthy. (A normal blood pressure is lower than 120 over 80.) With a plethora of drugs available to normalize blood pressure, why are so many people still at increased risk of disease, disability and premature death? Hypertension experts offer a few common, and correctable, reasons:


Jane Brody speaks about hypertension.




¶ About 20 percent of affected adults don’t know they have high blood pressure, perhaps because they never or rarely see a doctor who checks their pressure.

¶ Of the 80 percent who are aware of their condition, some don’t appreciate how serious it can be and fail to get treated, even when their doctors say they should.

¶ Some who have been treated develop bothersome side effects, causing them to abandon therapy or to use it haphazardly.

¶ Many others do little to change lifestyle factors, like obesity, lack of exercise and a high-salt diet, that can make hypertension harder to control.

Dr. Samuel J. Mann, a hypertension specialist and professor of clinical medicine at Weill-Cornell Medical College, adds another factor that may be the most important. Of the 71 percent of people with hypertension who are currently being treated, too many are taking the wrong drugs or the wrong dosages of the right ones.

Dr. Mann, author of “Hypertension and You: Old Drugs, New Drugs, and the Right Drugs for Your High Blood Pressure,” says that doctors should take into account the underlying causes of each patient’s blood pressure problem and the side effects that may prompt patients to abandon therapy. He has found that when treatment is tailored to the individual, nearly all cases of high blood pressure can be brought and kept under control with available drugs.

Plus, he said in an interview, it can be done with minimal, if any, side effects and at a reasonable cost.

“For most people, no new drugs need to be developed,” Dr. Mann said. “What we need, in terms of medication, is already out there. We just need to use it better.”

But many doctors who are generalists do not understand the “intricacies and nuances” of the dozens of available medications to determine which is appropriate to a certain patient.

“Prescribing the same medication to patient after patient just does not cut it,” Dr. Mann wrote in his book.

The trick to prescribing the best treatment for each patient is to first determine which of three mechanisms, or combination of mechanisms, is responsible for a patient’s hypertension, he said.

¶ Salt-sensitive hypertension, more common in older people and African-Americans, responds well to diuretics and calcium channel blockers.

¶ Hypertension driven by the kidney hormone renin responds best to ACE inhibitors and angiotensin receptor blockers, as well as direct renin inhibitors and beta-blockers.

¶ Neurogenic hypertension is a product of the sympathetic nervous system and is best treated with beta-blockers, alpha-blockers and drugs like clonidine.

According to Dr. Mann, neurogenic hypertension results from repressed emotions. He has found that many patients with it suffered trauma early in life or abuse. They seem calm and content on the surface but continually suppress their distress, he said.

One of Dr. Mann’s patients had had high blood pressure since her late 20s that remained well-controlled by the three drugs her family doctor prescribed. Then in her 40s, periodic checks showed it was often too high. When taking more of the prescribed medication did not result in lasting control, she sought Dr. Mann’s help.

After a thorough work-up, he said she had a textbook case of neurogenic hypertension, was taking too much medication and needed different drugs. Her condition soon became far better managed, with side effects she could easily tolerate, and she no longer feared she would die young of a heart attack or stroke.

But most patients should not have to consult a specialist. They can be well-treated by an internist or family physician who approaches the condition systematically, Dr. Mann said. Patients should be started on low doses of one or more drugs, including a diuretic; the dosage or number of drugs can be slowly increased as needed to achieve a normal pressure.

Specialists, he said, are most useful for treating the 10 percent to 15 percent of patients with so-called resistant hypertension that remains uncontrolled despite treatment with three drugs, including a diuretic, and for those whose treatment is effective but causing distressing side effects.

Hypertension sometimes fails to respond to routine care, he noted, because it results from an underlying medical problem that needs to be addressed.

“Some patients are on a lot of blood pressure drugs — four or five — who probably don’t need so many, and if they do, the question is why,” Dr. Mann said.


How to Measure Your Blood Pressure

Mistaken readings, which can occur in doctors’ offices as well as at home, can result in misdiagnosis of hypertension and improper treatment. Dr. Samuel J. Mann, of Weill Cornell Medical College, suggests these guidelines to reduce the risk of errors:

¶ Use an automatic monitor rather than a manual one, and check the accuracy of your home monitor at the doctor’s office.

¶ Use a monitor with an arm cuff, not a wrist or finger cuff, and use a large cuff if you have a large arm.

¶ Sit quietly for a few minutes, without talking, after putting on the cuff and before checking your pressure.

¶ Check your pressure in one arm only, and take three readings (not more) one or two minutes apart.

¶ Measure your blood pressure no more than twice a week unless you have severe hypertension or are changing medications.

¶ Check your pressure at random, ordinary times of the day, not just when you think it is high.

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The Media Equation: ‘South Park’ Creators Fortify Their Content Empire





When it comes to success stories in the entertainment world, it doesn’t get much better than the one about a pair of regular guys from Colorado, Matt Stone and Trey Parker, who took cutout paper dolls, animated them and triumphed on cable television, on the Web, at the multiplex and on Broadway.







Frederic J. Brown/Agence France-Presse — Getty Images

Matt Stone, left, and Trey Parker are forming a production company called Important Studios.







Last week, Mr. Stone arrived at a coffee shop in the Chelsea neighborhood of New York so bundled up that he resembled Kenny, who always shows up on “South Park” encased in a big orange parka. He was leaving the next day for London, where the fourth production of “The Book of Mormon” will soon begin a run.


Over the course of 16 seasons and 237 episodes, “South Park,” an assault on good taste built on the misadventures of four crudely animated and crudely spoken boys, has entered every pore of the culture. In the meantime, the two creators have helped put Comedy Central on the map, made four feature films, produced a sitcom and landed a Broadway hit with “Book of Mormon,” produced by Scott Rudin and Anne Garefino and created along with Robert Lopez.


Now Mr. Stone and Mr. Parker are about to finish a video game version of “South Park,” and they recently announced that they were forming a production company called Important Studios, valued at $300 million.


The success of “South Park” is a stark lesson in the fundamentals of entertainment: if you tell stories that people want to hear, the audience will find you.


This is true no matter how fundamentally the paradigms shift, or how many platforms evolve.


“We’ve been doing it long enough to figure out that content will ride on top of whatever wave comes along,” Mr. Stone said.


You might think that after all they’ve accomplished, they would be ready to step back a bit, and this is essentially true. Don’t worry, they aren’t going to actually kill Kenny, who for years was done away with in every episode. But “South Park,” which generally has been produced in two batches of seven episodes for a total of 14 every year, will be cut back to a single run of 10 episodes, beginning on Sept. 25.


“Why did we do seven and seven to begin with?” Mr. Stone said. “We just sort of made that up. And we are switching to 10 for the same reason. It just sounded like a good number, and we won’t break up the year so we can more easily do other stuff.”


The change sounds casually tossed off, but there is nothing unformed about the thinking that drives their choices.


“There is no appointment viewing anymore,” Mr. Stone said.


“In our first season, you had to show up on Wednesday nights at 10 p.m. on the comedy channel to catch the show. Now, I don’t even know where or how people watch our show. We sort of don’t really care about ratings. It’s more important to come up with work that will add to the library in a way that we’re proud of and will make people want to catch the show wherever they want to.”


That could happen on Netflix, on iTunes, on an ad-supported streaming format on Hulu, or hosted by the servers in the Los Angeles offices of Mr. Stone’s and Mr. Parker’s company.


The two men had the prescience to negotiate a 50-50 split on all digital revenue with Comedy Central, and part of the reason they remain so engaged is that they have real participation in the “South Park” enterprise.


“We have always owned our stuff or acted like we do,” Mr. Stone said as he worked his way through a late lunch. He pointed to Louis C. K., the comedian who took his last comedy special directly to fans on the Web, as an example of an artist moving to the sweet spot of the business that she or he creates.


“Owning your own stuff means that you control not only the content, but the life you are living while you are producing it,” he said.


“And then, if things go well, you can be part of the upside.”


Mr. Stone thinks it’s silly for creators to rely only on outside financing. Why drop years of sweat equity into creating something but not invest any cold hard cash?


“It took us four years to work out ‘Book of Mormon,’ and when you think of the opportunity cost of that — other projects that we walked by — it would be sort of silly not to put money in,” he said.


E-mail: carr@nytimes.com;


twitter.com/carr2n



This article has been revised to reflect the following correction:

Correction: January 28, 2013

An earlier version of this column misstated a plot point in “South Park.” While the character Kenny was once killed in every episode, that is no longer the case. The earlier version also misstated the circumstances of his repeated deaths. While he has met his fate in a variety of ways over the years, he was not routinely “ritually sacrificed.” 



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The Lede Blog: Fire at a Nightclub in Southern Brazil

Victims of the fire are attended by medics.

An intense fire ripped through a nightclub crowded with university students in southern Brazil early on Sunday morning, leaving behind a scene of horror, with bodies piled in the club’s bathrooms and on the street.

At least 232 people were killed, many of them students in the agronomy and veterinary medicine programs at a local university, police officials said.

As Simon Romero reports, a flare from a band’s pyrotechnic show ignited the fire in the nightclub, called Kiss, in the southern city of Santa Maria. Rescue workers continued to haul bodies from the still-smoldering building on Sunday.

Amateur videos posted to YouTube showed scenes of chaos as medics scurried over the bodies of victims who appeared to be unconscious, checking for signs of life.

Medics rush to care for victims of the fire.

Officials and witnesses say that security guards at the club had locked some exits, sewing panic as people attempted to flee the flames and smoke.

“Only after a multitude pushed down the security guards did they see the crap they had done,” Murilo de Toledo Tiecher, 26, a medical student who survived the fire, said in comments posted on Facebook.

Shortly before the fire, a club D.J. posted a photo on Facebook from inside the crowded club with the caption “Kiss is pumping.”

A short time later, another photo that was said to be taken outside the club and widely disseminated through social media showed smoke billowing from the front entrance.

The fire quickly engulfed the building.

Firefighters and volunteers who used T-shirts to protect themselves from the smoke struggled to pull people from the burning building.

Firefighters and volunteers tried to pull people from the burning building

Photos from the scene showed frantic friends and family members gathered outside the club and a hospital.

As Mr. Romero reports, witnesses said the fire started about 2 a.m. after the band, Gurizada Fangangueira, took the stage. At least one member of the five-person band, which is based in Santa Maria and advertised its use of pyrotechnics, was said to have been killed in the fire.

Overcrowding and a disregard for fire safety codes have led to deadly blazes at nightclubs in the past, though Sunday’s tragedy in Brazil is among the worst.

In 2003 in Rhode Island, a also fire set off by a pyrotechnic display at a club killed about 100 people. A fire that erupted under similar circumstances in Russia left almost as many dead in 2009.

And in Luoyang, China in 2000, 309 people were killed in a fire that broke out at a dance hall, forcing some to leap from high-rise windows.


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Smartphone pioneer RIM looks to put recent hardships behind it with BB10






TORONTO, Cananda – Once a leader but now derided as a laggard, BlackBerry-maker Research In Motion hopes to regain the confidence of cynical smartphone users this week as the curtain is lifted on its much-anticipated new smartphones.


The stakes are high for the unveiling, which many observers say will determine whether RIM survives to see the launch of another BlackBerry smartphone.






It has been a steep decline for RIM, which less than five years ago was the most valuable company in Canada, above Royal Bank (TSX:RY). Affectionately called the “CrackBerry” maker, the mobile communications pioneer was Canada’s crowning achievement of the technology sector.


Back in 1984, the year RIM was founded, it was practically unimaginable that a tiny startup based in Waterloo, Ont. would help change the way we communicate, but for fresh engineering graduates Mike Lazaridis and Douglas Fregin that was always the plan.


“Like so many of these guys Lazaridis was a Star Trek lunatic,” said Alastair Sweeny, author of “BlackBerry Planet.”


“He says it’s almost like telepathy — humans have a yearning to communicate.”


The beginnings were humble for the two founders, with the majority of their time dedicated to Budgie, an LED sign business that was contracted by General Motors to communicate messages to workers on its assembly lines. Despite early interest, the project was a sales flop and RIM‘s owners decided to sell the business and look at other ventures.


One of those projects put RIM squarely in the eyes of Hollywood. The DigiSync film reader caught on with movie editors because its synching technology shaved hours off the time it took to turn miles of film into useable content in post-production. While the technology went on to win RIM both an Emmy and a technical achievement from the Academy Awards, it was never a top priority for RIM‘s founders.


Lazaridis was always into security,” said Sweeny. “He realized that corporations needed secure communications because of industrial espionage, because of hacking.”


Throughout the late 1980s, RIM was working alongside other industry players to develop technology that would eventually be used in pagers and wireless payment processing systems. By the start of the 1990s, the wheels were turning on the communication systems that would become the foundation of the BlackBerry.


An agreement with Ericcson’s Mobitex wireless network allowed RIM to create pagers that operated as a two-way communicators, a revolutionary concept for data transfer.


Turning the idea into a marketable product was a bigger challenge. The world had yet to become accustomed to the Internet age and most people hadn’t heard of email, nevermind used it. While the project was a bust with its first partner Cantel, RIM forged ahead.


The technology captured the attention and imaginations of an industry, and perhaps most importantly Jim Balsillie, an energetic Harvard graduate who, at the age of 33, invested $ 250,000 of his own money into the company by re-mortgaging his house.


In 1996, RIM launched its first sales success, a clamshell wireless handheld device called the RIM 900 Interactive Pager. It was a two-way communicator that also had the ability to send faxes, as well as link to the Internet and email.


But Lazaridis discovered that the email feature, which he believed was one of the strongest qualities of the device, wasn’t being used by most customers. So he hired Lexicon Branding, based in California, to find a way to draw more attention to its keyboard, the main feature that differentiated it from other pagers.


Branding executives pondered the device, focusing mainly on its appearance, and when one of them pointed out the little keypad looked like similar to the seeds of a strawberry, the conversation zeroed in on the names of fruits and vegetables. Eventually, the group settled on “BlackBerry” because it was both punchy and remained true to the device’s original black casing.


The company listed on the Toronto Stock Exchange in 1997, raising more than $ 115 million, and debuted the first BlackBerry the following year.


From there it seemed the sky was the limit.


Suddenly the BlackBerry was everywhere in the technology community, thrust into the spotlight by the enthusiastic co-CEO Balsillie who touted the device on Wall Street and handed it out for free at select technology conferences. Balsillie knew how to build buzz and proudly tapped away on the BlackBerry whenever he appeared before the media.


A demand had been created, and subscribers to the BlackBerry services continued to grow in leaps and bounds. In 1999, RIM listed on the Nasdaq, raising another US$ 250 million.


The success grabbed the attention of Virginia-based NTP Inc. which filed a lawsuit claiming that RIM‘s network infringed on its patents. While NTP won the case, and the courts ordered RIM to pay US$ 23.1 million, the battle continued in appeals courts for years before a settlement was reached for a much heftier $ 612.5 million.


Outside the courtrooms the BlackBerry was a massive success, garnering headlines when its enterprise network remained intact after the terrorist attacks on Sept. 11 when other wireless phone systems broke down.


The BlackBerry’s reputation was growing at a steady clip, helped by the introduction of cellphone service in 2002 on what had been a text-only device. Within two years, BlackBerry reached more than 1 million subscribers.


The smartphone was in demand at corporate offices around the world, and soon the more casual consumer began to take notice, helping to boost its subscribers to nine million by 2007. RIM also secured a distribution deal in China, driving its stock to a level that made it the most valuable Canadian company.


But amid all of the success a storm of competition was brewing in the tech industry.


In June 2007, Apple unleashed the first iPhone touchscreen device onto the U.S. market, garnering widespread praise from critics and consumers, but hardly rattling its competitors.


Microsoft’s chief executive Steve Ballmer famously dismissed the touchscreen device that year, saying “there’s no chance that the iPhone is going to get any significant market share.”


Whether it was a strategic decision or simply coincidence, Apple kept its iPhone far away from the Canadian marketplace for nearly a year, choosing to launch in six other countries first.


The lower profile with Canadian consumers also seemed to minimize the concern from RIM’s executives, who publicly downplayed the influence of the iPhone in an already crowded mobile phone market.


“They just missed it,” said Carl Howe, vice-president of consumer research at Yankee Group.


“They missed the idea that you could create a really good experience without having a keyboard. They gave Apple a two-year head start.”


By the time the iPhone hit Canadian shelves, RIM was facing scrutiny from analysts who worried that the growing number competitors, which now also included Google’s Android system, would devour marketshare.


RIM went on the defensive in 2008, releasing a combination keypad and touchscreen device it called the Storm, but the phone was swept up in a flurry of other BlackBerry releases that year. Much of the marketing clout was put behind the debut of a high-end BlackBerry Bold, which wasn’t a touchscreen.


“A lot of tech companies have their heads in the sand,” said Howe of the co-CEOs.


“It’s not that they’re stupid, and I think that’s an important point. People who get hit by ‘innovator’s dilemma’ are not stupid … I think when you create something from scratch and turn it into a multi-billion dollar business you’re very reluctant to say ‘I’m now going to throw away everything I’ve learned and do something different.’ “


At the height of its hype, the BlackBerry device was splashed across television shows and movies, while then-presidential candidate Barack Obama proclaimed he was a BlackBerry faithful during his campaign.


As competition heated up with Apple, investors became concerned that RIM’s co-CEOs, in particular Balsillie, were distracted by the possibilities that success brought them, rather than focused on revamping the BlackBerry for a new era.


In 2009, Balsillie launched his third, and most aggressive, attempt to buy an National Hockey League team, with hopes that he could convince the NHL to move the Phoenix Coyotes to Hamilton. The battle dragged on for months before Balsillie abandoned his dream once again.


Back in Waterloo a storm was brewing as technical problems began to wreak havoc on the company’s network infrastructure.


There were two network outages in less than a year that left BlackBerry users temporarily without their services. Some industry observers suggested the company could buckle under its own success. BlackBerry sales were soaring, even with the technical problems, with subscriber growth up 70 per cent to 36 million by the end of 2009. RIM’s leaders reassured users that the outages were a fluke and wouldn’t be a reoccurring problem.


Despite the setbacks, the BlackBerry image appeared to emerge unscathed. In April 2010 it cracked the Top Five mobile phone carriers worldwide and soon afterwards Queen Elizabeth made a visit to RIM’s headquarters in Waterloo.


Behind the scenes there was unrest among the company’s board of directors as the leaders clashed over where the BlackBerry brand should go next. Rumours swirled around the industry that trouble was afoot.


Fanfare eventually gave way to the realities of competition, with the first major blow coming from the failed launch of the PlayBook, RIM’s answer to Apple’s iPad. In September 2010, the co-CEOs showcased the new product for the public but waited another six months before unleashing it to stores.


By then it was too late, the tablet market had already been cornered by Apple and reviews of the PlayBook harshly criticized its lack of connectivity to popular BlackBerry functions like email and instant messenger.


Within months the foundation of RIM started to crumble as it repeatedly missed its own revenue and earnings targets. In June 2011, the company slashed 11 per cent of its workforce, or 2,000 jobs, to keep its cost in line.


A stark reminder of its fragility came in October 2011 when a worldwide four-day outage left BlackBerry users again without the use of the device they had come to rely on. The smartphones wouldn’t connect to the Internet, email or its messaging services.


The anger from its loyal users was heard loud and clear, and Lazaridis emerged from days of silence to apologize and tell users the company had let them down.


In an earnings call several weeks later, Lazaridis urged investor “patience and confidence” as the executives tried to improve performance. Both he and Balsillie, two of the company’s biggest shareholders, reduced their salaries to $ 1.


Again, it was a decision made too late — the outage had cost RIM more than $ 50 million in revenue and tarnished its reputation. In December 2011, the company reported that profits tumbled more than 70 per cent, affected by a big charge from sales discounts it was forced make on PlayBook tablets.


Perhaps an even bigger blow to RIM’s reputation was the delay of its next-generation BlackBerrys, pushing the planned release into 2012. The phones — which were delayed again throughout last year and will be unveiled this Wednesday — were seen as the company’s best hope to maintain market share against Apple and Android devices.


The company stock had tumbled from its lofty height of $ 137.41 on the Toronto Stock Exchange in mid-2008 to $ 14.80 at the end of 2011.


RIM, once a symbol of Canadian success and innovation, had become awash in its own troubles. Apple’s iPhone had cornered the rapidly developing apps market while RIM sat on the sidelines with developers.


Sweeny recalls visiting a group of developers, who he considered BlackBerry fanatics, while doing research for his book in 2008.


“They were writing great games and programs for the BlackBerry and they couldn’t get the latest hardware from RIM to test them on,” he said.


“I called them a couple years later and they weren’t writing for BlackBerry at all. They were writing programs for Apple and starting to write for Android.”


From an outsider’s perspective, it’s often suggested that the co-CEOs lost control of their empire, but some industry watchers say that RIM saw the troubles several years earlier.


“In this market you can’t admit that you’re behind,” said Tim Long, an analyst at BMO Capital Markets.


“You have to put on the face because once you start to lose momentum that can shift the buying patterns.”


Numerous acquisitions were made by RIM throughout 2010 and 2011 to beef up its stable of technology, Long said. That included Ottawa-based QNX Software Systems, whose technology became the basis of the new operating system, and Astonishing Tribe, the Swedish company that helped develop an early user interface of the Android operating system.


But the acquisitions came too late, and by late 2011 some investors were calling for its leaders to resign.


Bowing to pressure, Balsillie and Lazaridis stepped down from their co-CEO positions in January 2012, pocketing a combined $ 12 million in the process. The duo were replaced by Thorsten Heins, RIM’s former chief operating officer, and hardly two months later Balsillie had left the company entirely.


Almost immediately, Heins launched a major revamp of RIM’s operations, hiring several new executives with experience at other major tech companies. The approach was a last-ditch effort to revive the company, but it has also thrown the BlackBerry maker into the most uncertain period in its history.


With nearly $ 2 billion in its coffers Heins had options, but the clock was ticking to get a new smartphone on the market.


“Nobody is delusional here,” Rick Costanzo, the company’s new executive vice-president of global sales, said last summer.


“We get it. That’s why we’re building BlackBerry 10 and man are we committed.”


A new chapter in RIM’s history begins this week as the BlackBerry 10 smartphones and operating system are showcased to the world.


Wireless News Headlines – Yahoo! News





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Celtics PG Rondo tore right ACL; surgery expected


BOSTON (AP) — Boston Celtics star point guard Rajon Rondo has torn his anterior cruciate ligament.


The injury usually takes up to a year for recovery, and he is expected to have surgery on his right knee.


The Celtics had lost six straight games heading into the Sunday afternoon meeting with the Miami Heat. Rondo reported to the arena for a pregame shootaround but was taken to a hospital after complaining of knee pain.


Rondo was voted by fans to be a starter in the Feb. 17 All-Star game in Houston.


He was averaging 13.7 points and 11.1 assists.


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Brain Aging Linked to Sleep-Related Memory Decline


For decades scientists have known that the ability to remember newly learned information declines with age, but it was not clear why. A new study may provide part of the answer.


The report, posted online on Sunday by the journal Nature Neuroscience, suggests that structural brain changes occurring naturally over time interfere with sleep quality, which in turn blunts the ability to store memories for the long term.


Previous research had found that the prefrontal cortex, the brain region behind the forehead, tends to lose volume with age, and that part of this region helps sustain quality sleep, which is critical to consolidating new memories. But the new experiment, led by scientists at the University of California, Berkeley, is the first to link structural changes directly with sleep-related memory problems.


The findings suggest that one way to slow memory decline in aging adults is to improve sleep, specifically the so-called slow-wave phase, which constitutes about a quarter of a normal night’s slumber.


Doctors cannot reverse structural changes that occur with age any more than they can turn back time. But at least two groups are experimenting with electrical stimulation as a way to improve deep sleep in older people. By placing electrodes on the scalp, scientists can run a low current across the prefrontal area, essentially mimicking the shape of clean, high-quality slow waves.


The result: improved memory, at least in some studies. “There are also a number of other ways you can improve sleep, including exercise,” said Ken Paller, a professor of psychology and director of the cognitive neuroscience program at Northwestern, who was not involved in the research.


Dr. Paller said that a whole array of changes occurred across the brain during aging and that sleep was only one factor affecting memory function.


But Dr. Paller said that the study told “a convincing story, I think: that atrophy is related to slow-wave sleep, which we know is related to memory performance. So it’s a contributing factor.”


In the study, a research team in California took brain images from 19 people of retirement age and 18 in their early 20s. It found that a brain area called the medial prefrontal cortex, roughly behind the middle of the forehead, was about a third smaller on average in the older group than in the younger one — a difference due to natural atrophy over time, previous research suggests.


Before bedtime, the team had the two groups study a long list of words paired with nonsense syllables, like “action-siblis” and “arm-reconver.” The team used such nonwords because one type of memory that declines with age is for new, previously unseen information.


After training on the pairs for half an hour or so, the participants took a test on some of them. The young group outscored the older group by about 25 percent.


Then everyone went to bed — and bigger differences emerged. For one, the older group got only about a quarter of the amount of high-quality slow-wave sleep that the younger group did, as measured by the shape and consistency of electrical waves on an electroencephalogram machine, or EEG. It is thought that the brain moves memories from temporary to longer-term storage during this deep sleep.


On a second test, given in the morning, the younger group outscored the older group by about 55 percent. The estimated amount of atrophy in each person roughly predicted the difference between his or her morning and evening scores, the study found. Even seniors who were very sharp at night showed declines after sleeping.


“The analysis showed that the differences were due not to changes in capacity for memories, but to differences in sleep quality,” said Bryce A. Mander, a postdoctoral fellow at Berkeley, and the lead author of the study. His co-authors included researchers from the California Pacific Medical Center in San Francisco; the University of California, San Diego; and the Lawrence Berkeley National Laboratory.


The findings do not imply that medial prefrontal atrophy is the only age-related change causing memory problems, said Matthew P. Walker, a professor of psychology and neuroscience at Berkeley, and a co-author of the study.


“But these things are interrelated,” Dr. Walker said. “Essentially, with time, the less and less tissue you have in this prefrontal area, the less and less quality deep wave sleep you get, the less and less you remember of content that you just learned.”


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Unboxed: Literary History, Seen Through Big Data’s Lens





ANY list of the leading novelists of the 19th century, writing in English, would almost surely include Charles Dickens, Thomas Hardy, Herman Melville, Nathaniel Hawthorne and Mark Twain.




But they do not appear at the top of a list of the most influential writers of their time. Instead, a recent study has found, Jane Austen, author of “Pride and Prejudice, “ and Sir Walter Scott, the creator of “Ivanhoe,” had the greatest effect on other authors, in terms of writing style and themes.


These two were “the literary equivalent of Homo erectus, or, if you prefer, Adam and Eve,” Matthew L. Jockers wrote in research published last year. He based his conclusion on an analysis of 3,592 works published from 1780 to 1900. It was a lot of digging, and a computer did it.


The study, which involved statistical parsing and aggregation of thousands of novels, made other striking observations. For example, Austen’s works cluster tightly together in style and theme, while those of George Eliot (a k a Mary Ann Evans) range more broadly, and more closely resemble the patterns of male writers. Using similar criteria, Harriet Beecher Stowe was 20 years ahead of her time, said Mr. Jockers, whose research will soon be published in a book, “Macroanalysis: Digital Methods and Literary History” (University of Illinois Press).


These findings are hardly the last word. At this stage, this kind of digital analysis is mostly an intriguing sign that Big Data technology is steadily pushing beyond the Internet industry and scientific research into seemingly foreign fields like the social sciences and the humanities. The new tools of discovery provide a fresh look at culture, much as the microscope gave us a closer look at the subtleties of life and the telescope opened the way to faraway galaxies.


“Traditionally, literary history was done by studying a relative handful of texts,” says Mr. Jockers, an assistant professor of English and a researcher at the Center for Digital Research in the Humanities at the University of Nebraska. “What this technology does is let you see the big picture — the context in which a writer worked — on a scale we’ve never seen before.”


Mr. Jockers, 46, personifies the digital advance in the humanities. He received a Ph.D. in English literature from Southern Illinois University, but was also fascinated by computing and became a self-taught programmer. Before he moved to the University of Nebraska last year, he spent more than a decade at Stanford, where he was a founder of the Stanford Literary Lab, which is dedicated to the digital exploration of books.


Today, Mr. Jockers describes the tools of his trade in terms familiar to an Internet software engineer — algorithms that use machine learning and network analysis techniques. His mathematical models are tailored to identify word patterns and thematic elements in written text. The number and strength of links among novels determine influence, much the way Google ranks Web sites.


It is this ability to collect, measure and analyze data for meaningful insights that is the promise of Big Data technology. In the humanities and social sciences, the flood of new data comes from many sources including books scanned into digital form, Web sites, blog posts and social network communications.


Data-centric specialties are growing fast, giving rise to a new vocabulary. In political science, this quantitative analysis is called political methodology. In history, there is cliometrics, which applies econometrics to history. In literature, stylometry is the study of an author’s writing style, and these days it leans heavily on computing and statistical analysis. Culturomics is the umbrella term used to describe rigorous quantitative inquiries in the social sciences and humanities.


“Some call it computer science and some call it statistics, but the essence is that these algorithmic methods are increasingly part of every discipline now,” says Gary King, director of the Institute for Quantitative Social Science at Harvard.


Cultural data analysts often adapt biological analogies to describe their work. Mr. Jockers, for example, called his research presentation “Computing and Visualizing the 19th-Century Literary Genome.”


Such biological metaphors seem apt, because much of the research is a quantitative examination of words. Just as genes are the fundamental building blocks of biology, words are the raw material of ideas.


“What is critical and distinctive to human evolution is ideas, and how they evolve,” says Jean-Baptiste Michel, a postdoctoral fellow at Harvard.


Mr. Michel and another researcher, Erez Lieberman Aiden, led a project to mine the virtual book depository known as Google Books and to track the use of words over time, compare related words and even graph them.


Google cooperated and built the software for making graphs open to the public. The initial version of Google’s cultural exploration site began at the end of 2010, based on more than five million books, dating from 1500. By now, Google has scanned 20 million books, and the site is used 50 times a minute. For example, type in “women” in comparison to “men,” and you see that for centuries the number of references to men dwarfed those for women. The crossover came in 1985, with women ahead ever since.


In work published in Science magazine in 2011, Mr. Michel and the research team tapped the Google Books data to find how quickly the past fades from books. For instance, references to “1880,” which peaked in that year, fell to half by 1912, a lag of 32 years. By contrast, “1973” declined to half its peak by 1983, only 10 years later. “We are forgetting our past faster with each passing year,” the authors wrote.


JON KLEINBERG, a computer scientist at Cornell, and a group of researchers approached collective memory from a very different perspective.


This article has been revised to reflect the following correction:

Correction: January 27, 2013

An earlier version of this article misstated Matthew L. Jockers’s age. He is 46, not 48. 



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Hackers claim attack on Justice Department website






WASHINGTON (Reuters) – Hackers sympathetic to the late computer prodigy Aaron Swartz claimed on Saturday to have infiltrated the website of the U.S. Justice Department’s Sentencing Commission, and said they planned to release government data.


The Sentencing Commission site, www.ussc.gov , was shut down early Saturday.






Identifying themselves as Anonymous, a loosely organized group of unknown provenance associated with a range of recent online actions, the hackers voiced outrage over Swartz’ suicide on January 11.


In a video posted online, the hackers criticized the government’s prosecution of Swartz, who had been facing trial on charges that he used the Massachusetts Institute of Technology‘s computer networks to steal more than 4 million articles from JSTOR, an online archive and journal distribution service.


Swartz had faced a maximum sentence of 31 years in prison and fines of up to $ 1 million.


The FBI is investigating the attack, according to Richard McFeely, of the bureau’s Criminal, Cyber, Response, and Services Branch.


“We were aware as soon as it happened and are handling it as a criminal investigation,” McFeely said in an emailed statement. “We are always concerned when someone illegally accesses another person’s or government agency’s network.”


(Reporting by Deborah Zabarenko; Editing by Vicki Allen)


Tech News Headlines – Yahoo! News





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